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发表于 2017-2-28 19:46:30 |只看该作者 |正序浏览
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  个人简历:于文全,男;出生年月:1984.1;最后学历:博士;职称:副教授,硕士生导师。

  学习经历:

  2003–2007   天津大学 药物科学与技术学院,本科

  2007–2012   天津大学 药物科学与技术学院,博士(硕博连读)

  2008–2012   美国 肝炎与病毒研究所,研究学者(博士联合培养)

  工作经历:

  2012.7–2013.12  郑州大学 化学与分子工程学院,讲师

  2014.1–2015.11  郑州大学 直聘副教授、硕士生导师

  2015.12–现今郑州大学 化学与分子工程学院,副教授、硕士生导师

  联系方式:

  地址:河南省郑州市科学大道100号,郑州大学 化学与分子工程学院

  邮箱:wenquan_yu@zzu.edu.cn

  研究方向:

  核苷类抗病毒新药的研发

  病毒感染引起的疾病(如:乙型肝炎、丙型肝炎、艾滋病等)是全球性的健康问题,在全世界范围内有:3.5–4亿的慢性乙型肝炎患者、1.8亿的丙型肝炎患者、3530万例艾滋病病毒(HIV)携带者和艾滋病患者。目前,临床上已有的药物仅能够抑制患者体内病毒的复制,但是并不能够治愈相应的疾病;与此同时,长期用药物后,病毒会产生一定的抗药性,从而降低药物的药效。因此,亟需开发新型的抗病毒药物来满足临床治疗的需求。核苷(酸)类药物作为中坚力量,在病毒感染的治疗中起到了重要的作用,它具有可以口服、对大多数病人有效、且副作用低等优点。因此设计、合成和开发新型的核苷类抗病毒药物,对于抗病毒感染的治疗意义重大。

  分子内C?X(X = C, N, O, S等)键的构建及其在有机、药物合成中的应用

  噁唑、吡唑、噁二唑、噻二唑等杂环化合物的结构广泛存在于具有生物活性的天然产物和合成的药物分子当中,因此,对于这些化合物的合成一直是有机化学家研究的热点。本课题组的另一个研究方向致力于使用低毒的氧化剂、催化剂,开发绿色、高效的分子内C?X(X = C, N, O, S等)化学键的构建新方法,用于上述含氧、氮、硫等杂环化合物的合成,并建立化合物库用于生物活性(如,与蛋白相互作用、抗肿瘤、抗病毒等)筛选。

  在研的科研项目:

  国家自然科学基金-青年基金(81302637),新型4'-叠氮氟代核苷衍生物的设计、合成及其抗乙肝病毒活性研究,2014.01–2016.12,23万,主持

  国家科技重大专项-重大新药创制(2015ZX09J15105-003-001),呼吸道腺病毒等特殊病毒感染治疗新技术及创新药物研发,2015.01–2018.12,156.59万,子课题负责人

  郑州大学优秀青年教师发展基金,新型氟代核苷类似物的设计、合成与抗肿瘤活性研究,2016.01–2018.12,30万,主持

  已完成的科研项目:

  中国博士后科学基金-特别资助(2014T70690),新型氟代核苷化合物的设计、合成及其抗HIV活性研究,2014.01–2015.10,15万 + 7.5万,主持

  中国博士后科学基金-一等资助(2013M530341),新型嘌呤类核苷化合物的合成及其抗乙肝病毒活性研究,2013.05–2015.10,8万 + 4万,主持

  横向项目(20150085A),盐酸氟西泮对照品原料的制备,2015.05–2015.10,10万,主持

  国家科技重大专项-重大新药创制(2014ZX09102003-013),阿兹夫定抗艾滋病一类新药的临床前研究,2014.01–2014.12,58.77万,第一参与人

  教学论文、项目:

  2015年,郑州大学化学与分子工程学院本科生科研训练项目:咪唑[1,2-a]吡啶类化合物的合成新方法研究(指导教师)

  2015年,发表教学教改论文1篇(独著):如何在有机化学实验教学中培养本科生的科研素质,教育教学论坛(CN 13-1399/G4),2015年,第20期,277-278

  2015年,参与省级教改项目1项(第三,2015-JSJYLX-001,河南省教育厅)

  2015年,河南省高等学校有机化学教学团队(团队成员,第十)

  2014年,参与河南省高校精品课程《有机化学》建设(第九,教育技术骨干,河南省教育厅)

  2013年,郑州大学化学与分子工程学院本科生科研训练项目:新型核苷类抗病毒药物的合成(指导教师)

  参编教材:

  高等学校“十二五”规划教材《有机化学(基础篇)》,2014年,化学工业出版社,ISBN: 978-7-12220-677-0

  高等学校“十二五”规划教材《有机化学(提高篇)》,2014年,化学工业出版社,ISBN: 978-7-12220-930-6

  讲授课程:有机化学、专业外语与文献检索、今日化学、有机化学实验、金属有机化学(研)等

  代表性论文:

  26. Wu He, Bin Zhou, Weijia Liu, Meizi Zhang, Zhenhua Shen, Zhifu Han, Qingwei Jiang, Qinghua Yang, Chuanjun Song, Ruiyong Wang, Tianhui Niu, Shengna Han, Lirong Zhang, Jie Wu, Feima Guo, Renbin Zhao, Wenquan Yu, Jijie Chai,* and Junbiao Chang.* "Identification of A Novel Small-molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)." Journal of Medicinal Chemistry, 2015, ASAP. DOI: 10.1021/acs.jmedchem.5b00702(2015影响因子:5.447,药化一区)

  25. Xianhai Tian, Lina Song, Ertong Li, Qiang Wang, Wenquan Yu,* Junbiao Chang.* "Metal-Free One-Pot Synthesis of 1,3-Diazaheterocyclic Compounds via I2-Mediated Oxidative C?N Bond Formation." RSC Advances, 2015, 5 (76), 62194-62201.(2015影响因子:3.840)

  24.  Lina Song, Xianhai Tian, Zhigang Lv, Ertong Li, Jie Wu, Yangxue Liu, Wenquan Yu,* Junbiao Chang.* "I2/KI-Mediated Oxidative N?N Bond Formation for the Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Aryl Amidines." Journal of Organic Chemistry, 2015, 80 (14), 7219-7225.(2015影响因子:4.721)

  23. Zhigang Lv, Wu He, Xianhai Tian, Jinfeng Kang, Yangxue Liu, Youmei Peng, Liyun Zheng, Qingduan Wang, Wenquan Yu,* Junbiao Chang.* "Design, Synthesis, and Biological Evaluation of New N4-Substituted 2'-Deoxy-2'-fluoro-4'-azido Cytidine Derivatives as Potent Anti-HBV Agents." European Journal of Medicinal Chemistry, 2015, 101, 103-110.(2015影响因子:3.447,药化二区)

  22.  Qinghua Yang, Jinfeng Kang, Liyun Zheng, Xue-Jun Wang, Na Wan, Jie Wu, Yan Qiao, Pengfei Niu, Sheng-Qi Wang, Youmei Peng, Qingduan Wang, Wenquan Yu,* Junbiao Chang.* "Synthesis and Biological Evaluation of 4-Substituted Fluoronucleoside Analogs for the Treatment of Hepatitis B Virus Infection." Journal of Medicinal Chemistry, 2015, 58 (9), 3693-3703.(2015影响因子:5.447,药化一区)

  21.  Pengfei Niu, Jinfeng Kang, Xianhai Tian, Lina Song, Hongxu Liu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation." Journal of Organic Chemistry, 2015, 80 (2), 1018-1024.(2015影响因子:4.721)

  20.  Qinghua Yang, Xuejie Zhao, Wenquan Yu, Wu He, Xianzhen Fang, Limin Zang, Na Wan, Qingduan Wang, Liyun Zheng,* Junbiao Chang.* "Anti-hepatitis B Virus Activity of α-DDB-FNCG, a Novel Nucleoside-Biphenyldicarboxylate Compound In Vitro and In Vivo." Journal of Pharmacological Sciences, 2014, 126 (3), 208-215.(2015影响因子:2.36)

  19. Xinting Zhang, Jinfeng Kang, Pengfei Niu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "I2-Mediated Oxidative C?N Bond Formation for Metal-free One-pot Synthesis of Di-, Tri- and Tetra-substituted Pyrazoles from alpha,beta-Unsaturated Aldehydes/Ketones and Hydrazines." Journal of Organic Chemistry, 2014, 79 (21), 10170–10178.(2015影响因子:4.721)

  18.  Bingjie Liu, Yueteng Zhang, Gang Huang, Xinting Zhang, Pengfei Niu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "A Concise Approach to Polysubstituted Oxazoles from N-Acyl-2-bromo Enamides via a Copper(I)/Amino Acid-catalyzed Intramolecular C–O Bond Formation." Organic & Biomolecular Chemistry, 2014, 12 (23), 3912–3923.(2015影响因子:3.562)

  17.  Bao-Juan Zhao, Wen-Quan Yu, Jun-Biao Chang,* Er-Tong Li, Qun-Shan Ding, Feng-Juan Li, Guang-Ying Chen, Na Wa. "Synthesis and Characterization of 3'-Deoxy-3'-fluoro-2'-O,3'-C-vinyl- ene Linked Bicyclic Uridine." Chemical Journal of Chinese Universities, 2014, 35 (1), 58–62.(2015影响因子:0.875)

  16.  Wenquan Yu,* Gang Huang, Yueteng Zhang, Hongxu Liu, Lihong Dong, Xuejun Yu, Yujiang Li, and Junbiao Chang.* "I2-Mediated Oxidative C–O Bond Formation for the Synthesis of 1,3,4-Oxadiazoles from Aldehydes and Hydrazides.", 2013, 78 (20), 10337–10343.(2015影响因子:4.721)

  15.  Chun-Hong Dong, Yue-Teng Zhang, Gang Huang, Jing-Jing Dong, Hong-Xu Liu, Xian-Hai Tian, Jing Wang, Zhi-Gang Lv, Li-Na Song, Wen-Quan Yu.* "A Solid Phase Approach to PDMP Analogs: A General Strategy for Combinatorial Library." Chinese Chemical Letters, 2013, 24 (9), 845–848.(2015影响因子:1.587)

  14.  Baoshan Chai, Shuyang Wang, Wenquan Yu, Huichao Li, Chuanjun Song, Ying Xu, Changling Liu,* Junbiao Chang.* "Synthesis of Novel Strobilurin-pyrimidine Derivatives and Their Antiproliferative Activity against Human Cancer Cell Lines." Bioorganic & Medicinal Chemistry Letters, 2013, 23 (12), 3505–3510.(2015影响因子:2.42)

  13.  Jie Wu, Wenquan Yu, Leixia Fu, Wu He, Yao Wang, Baoshan Chai, Chuanjun Song,* Junbiao Chang.* "Design, Synthesis, and Biological Evaluation of New 2'-Deoxy-2'-fluoro-4'-triazole Cytidine Nucleosides as Potent Antiviral Agents." European Journal of Medicinal Chemistry, 2013, 63, 739–745.(2015影响因子:3.447,药化二区)

  12.  Li-Yun Zheng, Li-Min Zang, Qing-Hua Yang, Wen-Quan Yu, Xian-Zhen Fang, Yu-Hai Zhang, Xue-Jie Zhao, Na Wan, Yue-Teng Zhang, Qing-Duan Wang, Jun-Biao Chang.* "Anti-hepatitis B Virus Activity of α-DDB-DU, A Novel Nucleoside Analogue, In Vitro and In Vivo." European Journal of Pharmacology, 2013, 702 (1–3), 258–263.(2015影响因子:2.532)

  11.  Jinhong Chang,* Travis K. Warren, Xuesen Zhao, Tina Gill, Fang Guo, Lijuan Wang, Mary Ann Comunale, Yanming Du, Dominic S. Alonzi, Wenquan Yu, Hong Ye, Fei Liu, Ju-Tao Guo, Anand Mehta, Andrea Cuconati, Terry D. Butters, Sina Bavari, Xiaodong Xu, Timothy M. Block. "Small Molecule Inhibitors of ER α-Glucosidases are Active against Multiple Hemorrhagic Fever Viruses." Antiviral Research, 2013, 98 (3), 432–440.(影响因子:3.925)

  10.  Andrea Cuconati,* Courtney Mills, Cally Goddard, Xianchao Zhang, Wenquan Yu, Haitao Guo, Xiaodong Xu, Timothy M. Block.* "Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells." PLoS ONE, 2013, 8 (1), e54595.(影响因子:3.73)

  9.Dawei Cai, Courtney Mills, Wenquan Yu, Ran Yan, Carol E. Aldrich, Jeffry R. Saputelli, William S. Mason, Xiaodong Xu, Ju-Tao Guo, Timothy M. Block, Andrea Cuconati,* Haitao Guo.* "Identification of the Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation." Antimicrobial Agents and Chemotherapy, 2012, 56 (8), 4277–4288.(影响因子:4.565)

  8.Wenquan Yu, Tina Gill, Lijuan Wang, Yanming Du, Hong Ye, Xiaowang Qu, Ju-Tao Guo, Andrea Cuconati, Kang Zhao, Timothy M. Block, Xiaodong Xu,* Jinhong Chang.* "Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection." Journal of Medicinal Chemistry, 2012, 55 (13), 6061–6075.(2015影响因子:5.447,药化一区)

  7.Wenquan Yu, Cally Goddard, Elizabeth Clearfield, Courtney Mills, Tong Xiao, Haitao Guo, John D. Morrey, Neil E. Motter, Kang Zhao, Timothy M. Block, Andrea Cuconati,* Xiaodong Xu.* "Design, Synthesis, and Biological Evaluation of Triazolo-pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion." Journal of Medicinal Chemistry, 2011, 54 (16), 5660–5670.(2015影响因子:5.447,药化一区)

  6.Xiaowang Qu, Xiaoben Pan, Jessica Weidner, Wenquan Yu, Dominic Alonzi, Xiaodong Xu, Terry Butters, Timothy Block, Ju-Tao Guo, Jinhong Chang.* "Inhibitors of Endoplasmic Reticulum α-Glucosidases Potently Suppress Hepatitis C Virus Virion Assembly and Release." Antimicrobial Agents and Chemotherapy, 2011, 55 (3), 1036–1044.(影响因子:4.565)

  5.Jinhong Chang,* Wouter Schul, Terry D. Butters, Andy Yip, Boping Liu, Anne Goh, Suresh B. Lakshminarayana, Dominic Alonzi, Gabriele Reinkensmeier, Xiaoben Pan, Xiaowang Qu, Jessica M. Weidner, Lijuan Wang, Wenquan Yu, Nigel Borune, Mark A. Kinch, Jamie E. Rayahin, Robert Moriarty, Xiaodong Xu, Pei-Yong Shi, Ju-Tao Guo, Timothy M. Block. "Combination of α-Glucosidase Inhibitor and Ribavirin for the Treatment of Dengue Virus Infection In Vitro and In Vivo." Antiviral Research, 2011, 89 (1), 26–34.(影响因子:3.925)

  4.Chunxiao Xu, Haitao Guo, Xiao-Ben Pan, Richeng Mao, Wenquan Yu, Xiaodong Xu, Lai Wei, Jinhong Chang, Timothy M. Block, Ju-Tao Guo.* "Interferons Accelerate the Decay of Replication-competent Nucleocapsids of Hepatitis B Virus." Journal of Virology, 2010, 84 (18), 9332–9340.(影响因子:5.076)

  3.Yan Chen, Tong Ju, Junwei Wang, Wenquan Yu, Yunfei Du,* Kang Zhao.* "Concurrent α-Iodination and N-Arylation of Cyclic β-Enaminones." Synlett, 2010 (2), 231–234.(影响因子:2.655)

  2.Wenquan Yu, Yunfei Du, Kang Zhao.* "PIDA-Mediated Oxidative C-C Bond Formation: Novel Synthesis of Indoles from N-Aryl Enamines." Organic Letters, 2009, 11 (11), 2417–2420.(2015影响因子:6.364)

  1.Jing Wei, Wen-Quan Yu, Qing-Zhi Gao.* "Advances in the Study of A2B Adenosine Receptor Antagonists." Acta Pharmaceutica Sinica, 2008, 43 (3), 241–246.(影响因子:1.085)

  发明专利:

  1.常俊标;于文全;张月腾;黄刚.4-取代胺基-2'-脱氧-2'-氟-4'-叠氮-β-D-胞苷类核苷化合物、制备方法及其应用.2014年,专利申请号:CN201410314043.7.

  会议摘要:

  3.Wenquan Yu. "Design, Synthesis, and Biological Evaluation of Triazolo-pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion." 8th Sino-US Chemistry Professors Conference. Jul. 2012, Kunming, China.

  2.Wenquan Yu, et al. "Design, Synthesis and Biological Evaluation of N-Alkylated DNJ Derivatives for the Treatment of Dengue Virus (DENV) Infection." Gordon Research Conference: High Throughput Chemistry & Chemical Biology. Jun. 2011, New Hampshire, USA.

  1.Wenquan Yu, et al. "Synthesis and Biological Evaluation of Triazolo-Pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion." 23rd International Conference on Antiviral Research, Apr. 2010, San Francisco, USA. (Antiviral Research, 2010, 86, A42)
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