陈晓岚教授——郑州大学化学与分子工程学院博士生导师

郑大考研网

陈晓岚教授，理学博士，硕士生导师

联系电话：13523451038

E-mail：chenxl@zzu.edu.cn

简历：生于1964年12月，河南省郑州市人。1983.9-1987.6，在郑州大学化学系学习，获得理学学士学位；1996.1-1997.1，在英国READING大学留学，主要从事天然产物化学研究；2001.9-2004.6，在郑州大学化学系攻读博士学位；2000-2005，郑州大学化学系副教授；2005年至今，郑州大学化学系教授；2006.8-2007.2，作为高级访问学者，在美国南加州大学化学药学系进行合作科研。

主要研究领域：

化学生物学、有机磷化学和天然药物化学。近几年来，系统开展了化学生物学、天然药物化学、有机磷化学等方面的研究，在药物结构改造和小分子与大分子相互作用方面开展了出色的工作, 合成了系列磷酰化黄酮化合物，并用荧光与ESI质谱法研究比较了黄酮及其磷酰化产物与蛋白的相互作用，并对改造的有机磷小分子化合物活性进行了研究，探讨了磷酰化黄酮抗肿瘤作用及其机理。与美国南加州大学药学化学系进行合作开展双膦荧光标记物的合成和作用机理的研究。相关的研究成果已发表在“Bioconjugate Chem.”, “Anal. Chem.” ,“Bioorg. Med. Chem.”, “Phosphorus, Sulfur Silicon Relat. Elem.” “J. Chin. Chem. Soc.”等国内外知名杂志上，“Anal. Chem.”上相关内容被 “Chem. Rev.”, “Nat. Prod. Rep.”, “J. Am. Soc. Mass Spectr.” 等引用，其中Chem. Rev. 用专门的段落对此项有意义的工作给予介绍。已经发表国内外论文40余篇，其中SCI 20余篇。

科研项目：

    1、肿瘤靶位蛋白与磷酰化黄酮的弱相互作用研究，国家自然科学基金（No. 20472076）项目主持

    2、磷酰化黄酮与蛋白弱相互作用和作用位点研究，省杰出青年基金项目 （No. 054100001400）项目主持

获奖情况：

1、聚维酮碘泡腾片的研制与开发，2000年河南省科技进步二等奖；

2、富马酸福莫特罗原料药的合成方法研究，2000年通过科学技术厅鉴定；

3、聚维酮碘泡腾片消毒杀菌剂的研制，2001年通过科学技术厅鉴定；

4、联苯类化合物的合成方法、反应机理、相关化合物合成，2006年河南省科学技术进步奖一等奖。

近年来主要发表的文章：

1. Chen Xiaolan, Yuan Jinwei, Zhang Shouren, Qu Lingbo, Zhao Yufen. Synthesis of the novel phosphoramidate derivatives of chrysin [J]. Phosphorus Sulfur Silicon Relat. Elem. 2009, (In print)

2. Yuan Jinwei, Chen Xiaolan, Qu Lingbo, Zhang Shouren, Lu Jiansha, Zhao Yufen. A Covenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-arylquinolone. [J]. Phosphorus Sulfur and Silicon Relat. Elem. 2009, (in print)

3. Jin-Wei Yuan, Xiao-Lan Chen, Ling-Bo Qu, Zhi-Bo Qu, Ya-Dong Zhou, Yu-Fen Zhao. Synthesis of a Novel Type of Phosphoramidate Derivatives of 2-Arylquinolone [J]. J. Chin. Chem. Soc. 2009, 56(1): 51-58.

4. YUAN Jin-Wei, CHEN Xiao-Lan, QU Ling-Bo, ZHU Yu, HUANG Xiao-Ying, ZHAO Yu-Fen. Synthesis and Crystal Structure of 5, 7-dimethoxy-2-phenylquinoline-4-yl Phenyloxy (N-L-alanine ethyl ester) Phosphoramidate [J]. Chin. J. Struct. Chem. 2009, 28(4): 498-502.

5．Kashemirov B A, Bala  J L F, Chen X L,  Ebetino F H, Xia Z, Russell R G G, Coxon F P, Roelofs A J , Rogers M J, McKenna C E. Fluorescently Labeled Risedronate and Related Analogues: “ Magic Linker” Synthesis. Bioconjugate Chem., 2008, 19, 2308-2310.

6. Chen Xiaolan, Qu Lingbo, Li Wenfeng, Yuan Jinwei, Zhao Yufen. Synthesis of phosphoryl amino acids chrysin esters [J]. Phosphorus, Sulfur and Silicon Relat. Elem. 2008, 183, 603-609.

7. Qu Lingbo, Shi Xiaona, Chen Xiaolan, Fan Libo. Synthesis of Solanesyl Phosphonate [J]. Phosphorus, Sulfur and Silicon Relat. Elem. 2008, 183, 631-635.

8. Zhang Liuji, Qu Lingbo, Zhang Baojun, Chen Xiaolan and Zhao Yufen. A Convenient Method for the Synthesis of Cyclophosphamide Analogues [J]. Phosphorus, Sulfur and Silicon Relat. Elem. 2008, 183, 799-803.

9. Qu Lingbo, Wang Ling, Chen Xiaolan, Yuan Jinwei, Yang Ran, Li Ping. Study on the interaction of bovine serum albumin with puerarin and its derivatives [J]. Acta Chinica Sinica, 2007, 65, 2417-2422.

10. Chen Xiao-lan, Qu Ling-bo, Yuan Jin-wei, Zhao Yu-fen. Synthesis of a novel type of phosphates of puerarin [J]. J. Chin. Chem. Soc. 2007, 54, 583-585.

11. Chen Xiao-lan, Shi Xiaona, Qu Lingbo, Yuan Jinwei, Lu Jiansha, Zhao Yufen. Synthesis of novel phosphorylated daidzein derivatives and ESI investigation on their non-covalent complexes with lysozyme [J]. Chin. J. Chem. 2007, 25, 1008-1013.

12. Qu Lingbo, Chen Xiaolan, Yang Ran, Wang Ling, Zeng Huajin. Investigation of the interaction between isoflavonoids and bovine serum albumin by fluorescence spectroscopy [J]. Chin. J. Chem. 2007, 25, 1151-1155.

13. Yang Ran, Chen Xiaolan, Li Ping, Qu Lingbo. Interaction between lysozyme and three flavones by fluorescence spectroscopy [J]. Chem. J. of Chin. Univer. 2006, 27, 1673-1676.

14. Guo Yuhua, Chen Xiaolan, Zhang Ting, Qu Lingbo, Zhao Yufen, Yu Youzhu. Study on the non-covalent interaction of 7-hydroxy flavone and its phosphate with DNA by fluorescence method [J]. Spectrosc. Spect. Anal. 2006, 26, 475-479.

15. Yuan Jinwei, Chen Xiaolan, Qu Lingbo, Liang Ruiling, Tang Mingsheng, Zhao Yufen. A Novel Conformation Investigation on Newly Synthesized Compound of Diethyl Puerarin-7-yl Phosphate [J]. Chin. J. Struct. Chem. 2006, 25, 78-84.

16. Chen Xiaolan, Qu Lingbo, Guo Lei, Lu Jiansha, Liu Yan, Wu Jianli, Zhao Yufen Study on the reaction of salicylic acid with dialkyl phosphite by NMR and electrospray ionization mass spectrometry [J]. Chin. J. Chem. 2005, 23, 733-739.

17. Chen Xiaolan, Qu Lingbo, Zhao Yufen. Studies on the Reaction of Salicylic Acid with Dialkyl phosphite by Electrospray Ionization Mass Spectrometry [J]. Chin. J. Chem. 2005, 23, 733-739.

18. Chen Xiaolan, Qu Lingbo, Liu Hongxia, Zhao Yufen. Study on the Nature of Phosphorylated Chrysin-Protein Interactions Involved in Noncovalent Complex Formation by Electrospray Ionization Mass Spectroscopy [J]. Anal. Chem. 2004, 76, 211-217.

19. Chen Xiaolan, Qu Lingbo, Liu Hongxia, Zhao Yufen. Direct observation of non-covalent complexes formed through phosphorylated-flavonoid protein interaction by electrospray ionization mass spectroscopy [J]. Supramol. Chem. 2004, 16, 67-75.

20. Zhang Ting, Chen Xiao-lan, Qu Ling-bo, Wu Jian-li, Cui Ran, Zhao Yu-fen. Chrysin and its phosphate ester inh Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells ibit cell proliferation and induce apoptosis in Hela cells [J]. Bioorg. Med. Chem. 2004, 12, 6097-6105.

21. Chen Xiaolan, Yu Youzhu, Qu Lingbo, Zhao Yufen. Synthesis of Novel Phosphoric Ester Flavone And Isoflavone By Atheron-Todd Reaction [J]. Synthetic Commun. 2004, 34, 493-499.

22. Chen Xiaolan, Qu Lingbo,Lu Jiansha, Zhao Yufen. Ortho effects in bis-phosphoric esters of the dihydroxy- and aminohydroxybenzenes observed by ESI-MS/MS [J]. Mass Spectrom. Soc. Japan, 2004, 52, 63-67.