陈鲤翔,博士,副教授,硕士生导师。2004年 毕业于兰州大学,生物化学与分子生物学专业,获理学博士学位。2008年至2013年期间以博士后身份于美国纽约血液中心,红细胞生理实验室从事红细胞骨架蛋白的结构与功能研究工作。期间主要科研研究方向为4.1蛋白对细胞运动的影响及机理以及4.1蛋白对肿瘤发病的影响及分子机理研究。发表SCI期刊收录论文10余篇,以第一作者身份在细胞生物学及分子生物学研究领域重要期刊Journal of Cell Science、Molecular and Cellular Biology和多肽研究领域重要期刊Peptide上发表多篇论文。单篇最高影响因子6.4。参与多项国家自然科学基金和省级科研项目。
论文 (近五年):
1. Hu J, Liu J, Xue F, Halverson G, Reid M, Guo A,Chen LX, Raza A, Galili N, Jaffray J, Lane J, Chasis JA, Taylor N, Mohandas N, An X.Isolation and functional characterization of human erythroblasts at distinct stages: Implications for understanding of normal and disordered erythropoiesis in vivo. Blood. 2013 Feb 19. [Epub ahead of print]
2.Chen LX, Hughes RA, Baines AJ, Conboy J, Mohandas N, An X.Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin.J Cell Sci. 2011 Jul 15;124(Pt 14):2478-87.
3. Yang S, Weng H,Chen LX, Guo X, Parra M, Conboy J, Debnath G, Lambert AJ, Peters LL, Baines AJ, Mohandas N, An X.Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility.Mol Cell Biol. 2011 Jun;31(11):2276-86.
4. Wu D, Gao Y,Chen LX(correspongding author), Qi Y, Kang Q, Wang H, Zhu L, Ye Y, Zhai M.Anti-tumor effects of a novel chimeric peptide on S180 and H22 xenografts bearing nude mice.Peptides. 2010 May;31(5):850-64.
5. Wang T,Chen LX, Wu W, Long Y, Wang R.Potential cytoprotection: antioxidant defence by caffeic acid phenethyl ester against free radical-induced damage of lipids, DNA, and proteins.Can J PhysiolPharmacol. 2008 May;86(5):279-87.
6. Wang T,Chen LX, Long Y, Wu WM, Wang R.DNA damage induced by caffeic acid phenyl ester in the presence of Cu(II) ions: potential mechanism of its anticancer properties.Cancer Lett. 2008 May 8;263(1):77-88.