2009年申请卫生厅和科技厅项目各一项,获人事厅资助项目一项。有发表两篇SCI杂志上。论文《Preclinical Studies Using Monoclonalantibody Anti-MUC1 and Docetaxel: A Novel Strategy for Targeting Advanced Epithelial Ovarian Cancer 》在亚太地区肿瘤会议上宣读并获大会“青年研究奖”。完成了卫生部协作攻关项目各一项。
近5年主持或承担的科研课题:
1、《晚期、复发性卵巢癌免疫和化疗联合靶向治疗候选靶位C595-MUC1的初探》
2、《单抗C595联合化疗药物治疗复发性卵巢癌的临床前期研究》
3、《uPA/uPAR对MMP的调控作用在上皮性卵巢癌中的临床意义》
4、《细胞侵袭试验技术在卵巢癌体外实验研究中的应用》
5、《腹腔镜微创技术在妇科恶性肿瘤诊治中的应用》
6、《荧光原位杂交技术检测宫颈癌hTERC基因扩增的临床应用研究》
7、《单抗C595对多烯紫杉醇的增敏作用在晚期和复发性卵巢癌中的作用及机理探讨》
8、《局部晚期宫颈癌的放化疗交叉耐受性研究》
近5年发表的文章:
1、 Li Wang, Jie Ma, FengHua Liu, QingKai Yu , GuangMin Chu, Alan C. Perkins, Yong Li.Expression of MUC1 in primary and metastatic human epithelial ovarian cancer and its therapeutic significance. Gynecologic Oncology, 2007;105:695-702.
3、 Li Wang, Michele C. Madigan, HongMin Chen, et al. Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients. Gynecologic Oncology,114(2009), 265-272.
4、 H Chen, J Hao, L Wang, et al. Coexpression of invasive markers (uPA, CD 44) and multiple drug-resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression. British Journal of cancer 2009(101), 432-440.
5、Hongmin Chen, Li Wang, Jiulia Beretov,et al.Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associate . Clin Exp etastasis (2010)27:557-569.
6、 Li Wang, Hongmin Chen, FengHua Liu,et al.Monoclonal antibody trargeting MUC1 and increasing sensitivity to docetaxel as a novel strategy intreating human epithelial ovarian cancer. Cancer Letters 300(2011) 122-133.
7、Li Wang, Hongmin Chen, Mohammad H Pourgholami, et al. Anti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model. September 2011 | Volume 6 | Issue 9 | e24405.